July 11, 2020 - 9:00 am
July 11, 2020 - 11:30 am
AddressSEC Centre View map
The past 4 decades highlighted the importance of glia, shifting the neurocentric vision of structure, function and pathology of nervous system to a more holistic perspective. In this view, the demand of technologies targeting the selective monitoring and control of glia is emerging as a challenge across Neuroscience, Engineering and Material Science.
This workshop aims to present the most promising advances in unconventional tools & methods, that enabled to reach unprecedented insights into the 4 dimensional (4D) nature of spatio-temporal neuron-glial interactions, in the healthy and pathological brain. Specifically, we will show how:
- (bio)materials as silicon nanowire, graphene or hydrogels can provide transition from 2D to 3D models, mimicking in-vivo structure, where to study healthy or reactive glial cells in vitro
- the use of nanostructured device allows stimulation and recording of astrocytes and neurons at different spatiotemporal scale
- computational approaches and control theory can reverse-engineer neuron-glial interactions
- combination of opto/chemogenetics, CLARITY and two-photon imaging reveals clues on significance of astrocytic domains in memory consolidation
- photonic and spectroscopic methods uncover the signature of microglial cells in pain.
The forum, presented by scientists from 5 different countries, will provide a multidisciplinary perspective on tools, potentially enabling to extend our knowledge on cognitive functions, pain and Alzheimer diseases.